SuicidDentistV1, Main, Exploration, bibRecord, 000191

Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.

Identifieur interne : 000191 ( Main/Exploration ); précédent : 000190; suivant : 000192

Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.

Auteurs : Rebecca Glover Andrews [États-Unis] ; Heather Baumhardt [États-Unis] ; Brian Martin [États-Unis] ; Dina Belachew [États-Unis] ; Miguel Reyes-Múgica [États-Unis]

Source :

Pediatric dentistry [ 1942-5473 ]

RBID : pubmed:25303511

Descripteurs français

English descriptors

KwdEn :
- Adolescent (MeSH), Bone Density Conservation Agents (therapeutic use), Calcitriol (therapeutic use), Calcium Channel Agonists (therapeutic use), Ergocalciferols (therapeutic use), Familial Hypophosphatemic Rickets (complications), Familial Hypophosphatemic Rickets (drug therapy), Follow-Up Studies (MeSH), Granuloma, Giant Cell (diagnosis), Granuloma, Giant Cell (etiology), Humans (MeSH), Hyperparathyroidism, Secondary (complications), Male (MeSH), Mandibular Diseases (diagnosis), Mandibular Diseases (etiology), Osteitis Fibrosa Cystica (diagnosis), Osteitis Fibrosa Cystica (etiology), Phosphates (therapeutic use).
MESH :
- chemical , therapeutic use : Bone Density Conservation Agents, Calcitriol, Calcium Channel Agonists, Ergocalciferols, Phosphates.
- complications : Familial Hypophosphatemic Rickets, Hyperparathyroidism, Secondary.
- diagnosis : Granuloma, Giant Cell, Mandibular Diseases, Osteitis Fibrosa Cystica.
- drug therapy : Familial Hypophosphatemic Rickets.
- etiology : Granuloma, Giant Cell, Mandibular Diseases, Osteitis Fibrosa Cystica.
- Adolescent, Follow-Up Studies, Humans, Male.

Abstract

A 14-year-old male with familial hypophosphatemic rickets, being treated with oral phosphate and calcitriol therapy, presented to the Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pa. A panoramic radiograph showed multifocal, multilocular lesions in the mandible leading to surgical exploration and biopsy. Histopathological evaluation of the largest lesion showed features consistent with central giant cell granuloma. Given the patient's history, hyperparathyroidism was suspected. Laboratory data showed an elevated parathyroid hormone of 152 pg/ml (normal range equals nine to 69). This confirmed the diagnosis of multiple brown tumors in the mandible associated with secondary hyperparathyroidism, which was attributed to high-dose phosphate treatment. After endocrinology consultation, calcitriol therapy was increased. Improvement of the patient's brown tumors is expected with medical therapy. The purpose of this case report was to raise awareness among pediatric dentists about the maxillofacial ramifications of secondary hyperparathyroidism.

PubMed: 25303511

Affiliations:

États-Unis

Links toward previous steps (curation, corpus...)

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Le document en format XML

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<sourceDesc><biblStruct><analytic><title xml:lang="en">Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.</title>
<author><name sortKey="Andrews, Rebecca Glover" sort="Andrews, Rebecca Glover" uniqKey="Andrews R" first="Rebecca Glover" last="Andrews">Rebecca Glover Andrews</name>
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<wicri:regionArea>Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, Pa.</wicri:regionArea>
<wicri:noRegion>Pa.</wicri:noRegion>
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<author><name sortKey="Baumhardt, Heather" sort="Baumhardt, Heather" uniqKey="Baumhardt H" first="Heather" last="Baumhardt">Heather Baumhardt</name>
<affiliation wicri:level="1"><nlm:affiliation>Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, Pa., USA.</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
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<author><name sortKey="Martin, Brian" sort="Martin, Brian" uniqKey="Martin B" first="Brian" last="Martin">Brian Martin</name>
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<author><name sortKey="Belachew, Dina" sort="Belachew, Dina" uniqKey="Belachew D" first="Dina" last="Belachew">Dina Belachew</name>
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<wicri:noRegion>Pa.</wicri:noRegion>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent (MeSH)</term>
<term>Bone Density Conservation Agents (therapeutic use)</term>
<term>Calcitriol (therapeutic use)</term>
<term>Calcium Channel Agonists (therapeutic use)</term>
<term>Ergocalciferols (therapeutic use)</term>
<term>Familial Hypophosphatemic Rickets (complications)</term>
<term>Familial Hypophosphatemic Rickets (drug therapy)</term>
<term>Follow-Up Studies (MeSH)</term>
<term>Granuloma, Giant Cell (diagnosis)</term>
<term>Granuloma, Giant Cell (etiology)</term>
<term>Humans (MeSH)</term>
<term>Hyperparathyroidism, Secondary (complications)</term>
<term>Male (MeSH)</term>
<term>Mandibular Diseases (diagnosis)</term>
<term>Mandibular Diseases (etiology)</term>
<term>Osteitis Fibrosa Cystica (diagnosis)</term>
<term>Osteitis Fibrosa Cystica (etiology)</term>
<term>Phosphates (therapeutic use)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Agents de maintien de la densité osseuse (usage thérapeutique)</term>
<term>Agonistes des canaux calciques (usage thérapeutique)</term>
<term>Calcitriol (usage thérapeutique)</term>
<term>Ergocalciférol (usage thérapeutique)</term>
<term>Granulome à cellules géantes (diagnostic)</term>
<term>Granulome à cellules géantes (étiologie)</term>
<term>Humains (MeSH)</term>
<term>Hyperparathyroïdie secondaire (complications)</term>
<term>Maladies mandibulaires (diagnostic)</term>
<term>Maladies mandibulaires (étiologie)</term>
<term>Mâle (MeSH)</term>
<term>Ostéite fibrokystique (diagnostic)</term>
<term>Ostéite fibrokystique (étiologie)</term>
<term>Phosphates (usage thérapeutique)</term>
<term>Rachitisme hypophosphatémique familial (complications)</term>
<term>Rachitisme hypophosphatémique familial (traitement médicamenteux)</term>
<term>Études de suivi (MeSH)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Bone Density Conservation Agents</term>
<term>Calcitriol</term>
<term>Calcium Channel Agonists</term>
<term>Ergocalciferols</term>
<term>Phosphates</term>
</keywords>
<keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Familial Hypophosphatemic Rickets</term>
<term>Hyperparathyroidism, Secondary</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Granuloma, Giant Cell</term>
<term>Mandibular Diseases</term>
<term>Osteitis Fibrosa Cystica</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Granulome à cellules géantes</term>
<term>Maladies mandibulaires</term>
<term>Ostéite fibrokystique</term>
</keywords>
<keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Familial Hypophosphatemic Rickets</term>
</keywords>
<keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Granuloma, Giant Cell</term>
<term>Mandibular Diseases</term>
<term>Osteitis Fibrosa Cystica</term>
</keywords>
<keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Rachitisme hypophosphatémique familial</term>
</keywords>
<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Agents de maintien de la densité osseuse</term>
<term>Agonistes des canaux calciques</term>
<term>Calcitriol</term>
<term>Ergocalciférol</term>
<term>Hyperparathyroïdie secondaire</term>
<term>Phosphates</term>
<term>Rachitisme hypophosphatémique familial</term>
</keywords>
<keywords scheme="MESH" qualifier="étiologie" xml:lang="fr"><term>Granulome à cellules géantes</term>
<term>Maladies mandibulaires</term>
<term>Ostéite fibrokystique</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Follow-Up Studies</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Humains</term>
<term>Mâle</term>
<term>Études de suivi</term>
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<front><div type="abstract" xml:lang="en">A 14-year-old male with familial hypophosphatemic rickets, being treated with oral phosphate and calcitriol therapy, presented to the Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pa. A panoramic radiograph showed multifocal, multilocular lesions in the mandible leading to surgical exploration and biopsy. Histopathological evaluation of the largest lesion showed features consistent with central giant cell granuloma. Given the patient's history, hyperparathyroidism was suspected. Laboratory data showed an elevated parathyroid hormone of 152 pg/ml (normal range equals nine to 69). This confirmed the diagnosis of multiple brown tumors in the mandible associated with secondary hyperparathyroidism, which was attributed to high-dose phosphate treatment. After endocrinology consultation, calcitriol therapy was increased. Improvement of the patient's brown tumors is expected with medical therapy. The purpose of this case report was to raise awareness among pediatric dentists about the maxillofacial ramifications of secondary hyperparathyroidism. </div>
</front>
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<DateCompleted><Year>2015</Year>
<Month>10</Month>
<Day>06</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>10</Month>
<Day>11</Day>
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<Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1942-5473</ISSN>
<JournalIssue CitedMedium="Internet"><Volume>36</Volume>
<Issue>5</Issue>
<PubDate><MedlineDate>2014 Sep-Oct</MedlineDate>
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<Title>Pediatric dentistry</Title>
<ISOAbbreviation>Pediatr Dent</ISOAbbreviation>
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<ArticleTitle>Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.</ArticleTitle>
<Pagination><MedlinePgn>422-4</MedlinePgn>
</Pagination>
<Abstract><AbstractText>A 14-year-old male with familial hypophosphatemic rickets, being treated with oral phosphate and calcitriol therapy, presented to the Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of the University of Pittsburgh Medical Center, Pittsburgh, Pa. A panoramic radiograph showed multifocal, multilocular lesions in the mandible leading to surgical exploration and biopsy. Histopathological evaluation of the largest lesion showed features consistent with central giant cell granuloma. Given the patient's history, hyperparathyroidism was suspected. Laboratory data showed an elevated parathyroid hormone of 152 pg/ml (normal range equals nine to 69). This confirmed the diagnosis of multiple brown tumors in the mandible associated with secondary hyperparathyroidism, which was attributed to high-dose phosphate treatment. After endocrinology consultation, calcitriol therapy was increased. Improvement of the patient's brown tumors is expected with medical therapy. The purpose of this case report was to raise awareness among pediatric dentists about the maxillofacial ramifications of secondary hyperparathyroidism. </AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Andrews</LastName>
<ForeName>Rebecca Glover</ForeName>
<Initials>RG</Initials>
<AffiliationInfo><Affiliation>Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, Pa., USA. rebecca.glover.andrews@gmail.com.</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Baumhardt</LastName>
<ForeName>Heather</ForeName>
<Initials>H</Initials>
<AffiliationInfo><Affiliation>Division of Pediatric Dentistry, Children's Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, Pa., USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Martin</LastName>
<ForeName>Brian</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Division of Pediatric Dentistry, Division of Pediatric Dentistry; at the Children's Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, Pa., USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Belachew</LastName>
<ForeName>Dina</ForeName>
<Initials>D</Initials>
<AffiliationInfo><Affiliation>Division of Endocrinology, Diabetes, and Metabolism; at the Children's Hospital of Pittsburgh of UPMC (University of Pittsburgh Medical Center), Pittsburgh, Pa., USA.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Reyes-Múgica</LastName>
<ForeName>Miguel</ForeName>
<Initials>M</Initials>
<AffiliationInfo><Affiliation>Children's Hospital of Pittsburgh of UPMC, USA; University of Pittsburgh School of Medicine, Pittsburgh, Pa., USA.</Affiliation>
</AffiliationInfo>
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<Language>eng</Language>
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<MedlineJournalInfo><Country>United States</Country>
<MedlineTA>Pediatr Dent</MedlineTA>
<NlmUniqueID>7909102</NlmUniqueID>
<ISSNLinking>0164-1263</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D050071">Bone Density Conservation Agents</NameOfSubstance>
</Chemical>
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<NameOfSubstance UI="D002120">Calcium Channel Agonists</NameOfSubstance>
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<CitationSubset>IM</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D050071" MajorTopicYN="N">Bone Density Conservation Agents</DescriptorName>
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</MeshHeading>
<MeshHeading><DescriptorName UI="D002117" MajorTopicYN="N">Calcitriol</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
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<MeshHeading><DescriptorName UI="D002120" MajorTopicYN="N">Calcium Channel Agonists</DescriptorName>
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<MeshHeading><DescriptorName UI="D004872" MajorTopicYN="N">Ergocalciferols</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D053098" MajorTopicYN="N">Familial Hypophosphatemic Rickets</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
<QualifierName UI="Q000188" MajorTopicYN="N">drug therapy</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D005500" MajorTopicYN="N">Follow-Up Studies</DescriptorName>
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<MeshHeading><DescriptorName UI="D006101" MajorTopicYN="N">Granuloma, Giant Cell</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006962" MajorTopicYN="N">Hyperparathyroidism, Secondary</DescriptorName>
<QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D008336" MajorTopicYN="N">Mandibular Diseases</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010002" MajorTopicYN="N">Osteitis Fibrosa Cystica</DescriptorName>
<QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName>
<QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D010710" MajorTopicYN="N">Phosphates</DescriptorName>
<QualifierName UI="Q000627" MajorTopicYN="N">therapeutic use</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
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<Month>10</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
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<Month>10</Month>
<Day>11</Day>
<Hour>6</Hour>
<Minute>0</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>2015</Year>
<Month>10</Month>
<Day>7</Day>
<Hour>6</Hour>
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<tree><country name="États-Unis"><noRegion><name sortKey="Andrews, Rebecca Glover" sort="Andrews, Rebecca Glover" uniqKey="Andrews R" first="Rebecca Glover" last="Andrews">Rebecca Glover Andrews</name>
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<name sortKey="Baumhardt, Heather" sort="Baumhardt, Heather" uniqKey="Baumhardt H" first="Heather" last="Baumhardt">Heather Baumhardt</name>
<name sortKey="Belachew, Dina" sort="Belachew, Dina" uniqKey="Belachew D" first="Dina" last="Belachew">Dina Belachew</name>
<name sortKey="Martin, Brian" sort="Martin, Brian" uniqKey="Martin B" first="Brian" last="Martin">Brian Martin</name>
<name sortKey="Reyes Mugica, Miguel" sort="Reyes Mugica, Miguel" uniqKey="Reyes Mugica M" first="Miguel" last="Reyes-Múgica">Miguel Reyes-Múgica</name>
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	Serveur d'exploration sur le suicide chez les dentistes
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Serveur d'exploration sur le suicide chez les dentistes

Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.

Oral manifestations of hyperparathyroidism secondary to familial hypophosphatemic rickets.

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